Probably not, but it is an interesting and somewhat tantalizing idea.
In 1882 a magnificent 400-year old series of painted panels were (re)discovered in a Lisbon church. Painted between 1471 and 1482, by Nuno Gonçalves, these Boards or Panels of Saint Vincent depict various ecclesiastical and court personalities in 15th century Portugal. I will leave the symbolism and interpretations to the art historians. But of interest is a figure who appears on the sixth panel. Wearing a six pointed red star, he must be a Jew, as Jews were required then to wear such a symbol on their clothing, holding open a Bible with some indeterminate characters.
Although I do not think this is the mainstream opinion, some scholars argued that this man must be/ could only be/ hopefully was, none other than Rabbi Isaac Abarbanel. Others are less certain, and will only agree that he must be a rabbi, or certainly a Jew.
In 1968 Charles Sterling and Jean Rosenwald wrote an article on 'The Panels of Saint Vincent and their Enigmas' (French) in L'Œil (1968), n° 159. Taking the position that it is Abarbanel, they made the following arguments.
First, he is beardless. Other depictions of Portuguese rabbis showed them with beards. Abarbanel was not a rabbi, at least nor professionally, and at least not then. He was, rather, a figure of the Portuguese royal court. Secondly, and more dubiously, the Bible that he is holding is opened roughly two thirds which is where the Prophets are located. Furthermore, some say that the Bible which Saint Vincent holds, elsewhere in the panel, is opened to John 14:30-31. I haven't seen a clear enough image to know if this is so. In Christian exegesis, these verses in John find its parallel in Isaiah 66:18-19. It is clear that actual Hebrew is not written in the Bible the Jewish man is holding, so historians basically have to guess based on the shape of the fake letters and the fact that it is a Jew holding it, that it is a Hebrew Bible. Some argue, however, that it is a Latin Bible, in Gothic characters. Again, not having seen a clear high resolution image I wonder if the Saint Vincent Bible is actually in clear characters and if the identification of the passage as John 14 is accurate or a guess.
Abarbanel is identified with his biblical commentaries (which, I might add, were authored years and even decades in some case after these panels were painted) and as a theologian. Thirdly, they note that as a Jew of high standing Abarbanel was specifically exempted by the king from wearing the six-pointed red star. If so, what to do about the fact that this man wears the star? They claimed that examination of the panels indicate that the red star was added later and this can be seen by the way it does not naturally flow with the material of the cloak. I might say that if this is so then we might have to be at least cautious that this man is Jewish altogether. Another thing I think has to at least be pointed out is that Abarbanel was born in 1437. Now, the precise date of the panels is unknown. Some sources indicate between 1471 and 1482, as I wrote at the beginning. Wikipedia paskens the 1460s, or at least between 1450 and 1471. Goncalves' page would seem to indicate that as late as 1490 was a possibility (see here). Nevertheless, Abarbanel fled to Castile in 1483, so if the famous Jewish court figure Abarbanel is truly being depicted, we ought to assume that it was prior to 1483.
Now I ask you: if we assume 1470s, is this the face of a man born some 35 years earlier or less? I doubt it.
Here is the panel, followed by a detail: